The diversity of metabolic reprogramming mechanisms in immune cells widely contributes to consequences on the cardio-vascular system. This deteriorative consequences are of complex nature and rely on heterogeneous pathogenic/non-pathogenic stimuli (1, 2). We aimed at studying the effect of hyperglycaemia on transforming growth factor beta 1 (TGFβ1) in immune cells and were able to demonstrate its dual role in monocytes/Macrophages. Furthermore, our results show how different pathogenic stimuli may modulate metabolism in immune cells and to what extent this could affect cardio-vascular deteriorative consequences. Results show specific glycolysis/stimulus pattern suspecting a leading a role of TGFβ1 signaling under different glucose concentrations in human monocytes/macrophages. In conclusion, hyperglycaemia is an essential metabolic factor that based on the environmental stimuli of the immune cells may contribute to deteriorative cardio-metabolic consequences.
My research concerns human immune cells responses to different pathogenic and non-pathogenic stimuli as well as the interaction of these cells with the surrounding nerves or vascular neighboring cells. So, my previous work within years of experiences in different scientific schools in Egypt, Finland and Germany focused on the responses of these cells to pathogens such as influenza viruses’ strains as well as signals from abnormal environmental contexts such like hyperglycaemia or tumor cells. In this sense, I targeted diseases such as diabetes, influenza virus infection and cancers specifically the brain tumor glioblastoma. My last degree obtained from Cairo University is my PhD in Pharmaceutical Sciences “Biochemistry”, holding at the moment the position of a researcher at the National Research Centre of Egypt.
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